After working at a video store where he wrote the scripts for some of his films, Paco Cabezas directed a few Spanish movies. In 2010, he began to gain attention with Neon Flesh, which debuted at the Tribeca Film Festival. After that, he began working in Hollywood, shooting Mr. Right, which premiered as the closing film at TIFF in 2015.
Cabezas' television directing credits include the season finale of Penny Dreadful, Fear the Walking Dead, and The Alienist.