When Texas preacher Jesse Custer is inhabited by the renegade spawn of an angel and a demon, he gains the power to control people with just a word. Now Jesse, his badass ex Tulip, and his friend Cassidy (who happens to be a vampire) are thrust into a twisted battle spanning Heaven, Hell and everywhere in between.
We get our first glimpse of the enigmatic Cowboy whose story of the past parallels the present-day. Jesse is hunted by two angels looking for the escaped entity inside him. Then, meet the richest, most sinful man in town.
The angels reveal all to Jesse about the true nature of his power, known as Genesis. An even more powerful angel comes to Annville to also hunt Jesse down. A tense argument with Arseface ends in disaster.
Jesse is on the run from Sheriff Root, but plans to save his church by literally calling down God. Emily makes a drastic choice to help Cassidy. The Cowboy exacts revenge on the town of Ratwater, which has a surprising connection to Annville.