Pardners in crime Newman (Butch Cassidy) and Redford (the Sundance Kid) are at the top of their respective games.
Wayne (as Sheriff John Chance) and Martin's longtime familiarity with each other lends added depth to their characters' rapport.
Good guy Logan (Freeman) teams up with his bad-boy buddy Munny (Eastwood) in an inimitable pairing of two dramatic greats.
In a stroke of genius casting, Hollywood's go-to guys for ornery tough-guy charm join forces to great affect.
As Wyatt Earp and his anemic friend Doc Holliday, Russell and Kilmer make riveting movie magic whenever they're together on-screen.
Jesse (Power) and Frank James (Fonda) team up to masterfully convey the forceful bond between two brothers on the trail.
A wise-cracking train robber (Wilson) is the perfect foil for the fish-out-of-water Chinese soldier (Chan) he encounters out west.
The subtle emotional relationship between the Kid (Newman) and a rancher he befriends (Keith-Johnston) hits all the right notes.
Sam Peckinpah brings out the best in Kristofferson and Coburn, who play off each other perfectly as two sides of the same soul.
Johnny Depp brings his trademark charm to the role of a mild accountant, with Farmer's spiritual Native American providing the perfect contrast.